Overview of the main physiological effects of THC

Psyche and perception: fatigue, euphoria, enhanced well-being, dysphoria, anxiety, reduction of anxiety, depersonalization, increased sensory perception, heightened sexual experience, hallucinations, alteration of time perception, psychotic states.

Cognition and psychomotoric performance: fragmented thinking, enhanced creativity, disturbed memory, unsteady gait, ataxia, slurred speech, deterioration or amelioration of motor coordination.

Nervous system: analgesia, muscle relaxation, appetite stimulation, vomiting, antiemetic effects, neuroprotection in ischemia and hypoxia.

Body temperature: decrease of body temperature.

Cardiovascular system: tachycardia, enhanced heart activity and increase in oxygen demand, vasodilation, orthostatic hypotension, hypertension (in horizontal position), inhibition of platelet aggregation.

Eye: injected (reddened) conjunctivae, reduced tear flow, decrease of intraocular pressure.

Respiratory system: bronchodilation, hyposalivation and dry mouth.

Gastrointestinal tract: reduced bowel movements and delayed gastric emptying.

Hormonal system: influence on LH, FSH, testosterone, prolactin, somatotropin, TSH, glucose metabolism, reduced sperm count and sperm motility, disturbed menstrual cycle and suppressed ovulation.

Immune system: impairment of cell-mediated and humoral immunity, anti-inflammatory and im¬munestimulating effects.

Fetal development: malformations, growth retardation, impairment to fetal and postnatal cerebral development, impairment of cognitive functions.

Genetic material and cancer: antineoplastic activity, inhibition of synthesis of DNA, RNA and proteins.

Source: Pharmacology, toxicology, and therapeutic potential. Binghamton/New York: Haworth Press, 2002.