It is unlikely to develop an addiction when cannabis is used as a medicine. The recommended dose for medicinal use is often lower than that for recreational use, and a medical professional should be involved in monitoring the patient.

Patients should take particular care, however, if they have been addicted in the past. High dosages of medicinal cannabis taken over a longer period may lead to addiction. Quitting may then cause withdrawal symptoms, such as mild forms of restlessness, irritability, insomnia and nausea.

Here we review previous research on the acute and long-term effects of cannabis use on the brain and behavior, and find that the three-stage framework of addiction applies to CUD in a manner similar to other drugs of abuse, albeit with some slight differences. These findings highlight the urgent need to conduct research that elucidates specific neurobiological changes associated with CUD in humans. Reference